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LLMs are advancing healthcare by offering new possibilities in clinical support, especially through tools like Microsoft’s BioGPT and Google’s Med-PaLM. Despite these innovations, LLMs in healthcare face a significant challenge: aligning with the professionalism and precision required for real-world diagnostics. This gap is particularly crucial under FDA regulations for Software-as-a-Medical-Device (SaMD), where LLMs must demonstrate specialized expertise. Current models, designed for general tasks, often need to meet the clinical standards required for life-critical healthcare environments, making their professional integration an ongoing challenge.
LLMs have advanced in processing unstructured medical data. However, concerns about their domain-specific expertise in critical clinical settings must be addressed. Recent work, like ZODIAC, aims to address these limitations by focusing on cardiological diagnostics. Multi-agent frameworks, widely used in healthcare for managing complex workflows, show promise in optimizing tasks like patient care coordination. However, cardiological diagnostic systems have mostly relied on rule-based or single-agent models, with deep learning models making recent strides. Incorporating LLMs into cardiology remains an underexplored area that this work seeks to advance.
Researchers from ZBeats Inc., New York University, and other institutions present ZODIAC, an LLM-powered system designed to achieve cardiologist-level professionalism in cardiological diagnostics. ZODIAC assists by extracting key patient data, detecting arrhythmias, and generating preliminary reports for expert review. Built on a multi-agent framework, ZODIAC processes multimodal data and is fine-tuned with real-world, cardiologist-verified inputs. Rigorous clinical validation shows ZODIAC outperforms leading models like GPT-4o and BioGPT. Successfully integrated into electrocardiography devices, ZODIAC sets a new standard for aligning LLMs with SaMD regulations, ensuring safety and accuracy in medical practice.
The ZODIAC framework is designed for cardiologist-level diagnostics using a multi-agent system that processes multimodal patient data. It collects biostatistics, tabular metrics, and ECG tracings, which different agents analyze. One agent interprets tabular metrics, while another evaluates ECG images, generating clinical findings. A third agent synthesizes these findings with clinical guidelines to create a diagnostic report. The process, validated by cardiologists, aligns with real-world medical practices and adheres to regulatory standards for SaMD, ensuring professional accuracy and compliance during hospital deployments.
The clinical validation experiments follow real-world settings, focusing on eight evaluation metrics. Five metrics assess clinical output quality, while three focus on security. Cardiologists were engaged to evaluate the ZODIAC framework, rating it on a scale of one to five using anonymized models to prevent bias. ZODIAC outperformed general and medical-specialist models, excelling in clinical professionalism and security. Subgroup analysis revealed ZODIAC’s consistent diagnostic performance across diverse populations. An ablation study confirmed the importance of fine-tuning and in-context learning, with ZODIAC also demonstrating high stability in repeated diagnostic outputs.
In conclusion, the study introduce ZODIAC, an advanced framework powered by LLMs for cardiology diagnostics, aimed at enhancing the collaboration between clinicians and LLMs. Utilizing cardiologist-validated data, ZODIAC employs instruction tuning, in-context learning, and fact-checking to deliver diagnoses comparable to human specialists. Clinical validation reveals ZODIAC’s superior performance across various patient demographics and arrhythmia types, outperforming leading models such as OpenAI’s GPT-4o and Microsoft’s BioGPT. The framework’s multi-agent collaboration processes diverse patient data, leading to accurate arrhythmia detection and preliminary report generation, marking a significant advancement in integrating LLMs into medical devices, including electrocardiography equipment.
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“}]] [[{“value”:”LLMs are advancing healthcare by offering new possibilities in clinical support, especially through tools like Microsoft’s BioGPT and Google’s Med-PaLM. Despite these innovations, LLMs in healthcare face a significant challenge: aligning with the professionalism and precision required for real-world diagnostics. This gap is particularly crucial under FDA regulations for Software-as-a-Medical-Device (SaMD), where LLMs must demonstrate
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